The Brain & Behavior Research Foundation has awarded more than $175 million to Schizophrenia Research since 1987. This could help pinpoint who may respond better to treatments.". Are attenuated positive symptoms and cortisol levels associated? Risk of withdrawal of consent for treatment with long-acting injectable versus oral antipsychotics: A meta … A multidisciplinary approach is essential to help individuals with this health condition, and psychological … The Schizophrenia Research Institute is the only national medical research institute solely dedicated to discovering the ways to better treat, prevent and cure schizophrenia. Those neurons could be studied in a virtual biopsy and compared to neurons engineered from individuals who did not have schizophrenia, but came from the same family from a homogenous population in the Central Valley of Costa Rica. Among the differentially expressed genes the researchers saw in the virtual biopsies were five that have previously been identified as schizophrenia candidate genes by genome-wide association studies. No other disorder arouses as much anxiety in the general public, the media, and doctors. Distinguished Professor Xu-Feng Huang is a National Health and Medical Research Council (NHMRC) Leadership Fellow who received a 2019 NHMRC Investigator grant for schizophrenia research. Schizophrenia Articles Schizophrenia is one of the most serious and frightening of all mental illnesses. Schizophrenia is a complex, heterogeneous disorder, with highly variable treatment outcomes, and relatively little is known about what is important to patients. (8) Book reviews. For schizophrenia, a dose range of 37–148 mg daily is recommended, with a lower dose range of 18.5–120 mg daily, recommended for bipolar depression (lurasidone at lower doses of 20–60 mg daily has been shown to be as clinically efficacious in bipolar depression, as at the higher dose range of 80–100 mg/day). Treatment is directed at ameliorating acute psychosis and reducing relapses. Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients. The precise mechanism whereby raloxifene enhances cognition is not clear. Relationship between allostatic load and clinical outcomes in youth at ultra-high risk for psychosis in the NEURAPRO study, Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium, Thalamus-related anomalies as candidate mechanism-based biomarkers for psychosis, Immuno-inflammatory changes across phases of early psychosis: The impact of antipsychotic medication and stage of illness, Reprint of: Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood, Grey-matter abnormalities in clinical high-risk participants for psychosis, Guest Editorial: Special issue on “Biomarkers in the attenuated psychosis syndrome”, Risk of withdrawal of consent for treatment with long-acting injectable versus oral antipsychotics: A meta-analysis of randomized controlled trials, Echo of reading - The forgotten psychopathology: A case report, Psychotic experiences in seven-year-old children with familial high risk of schizophrenia or bipolar disorder in: The Danish High Risk and Resilience Study – VIA 7; A population-based cohort study, A new 3-hit mouse model of schizophrenia built on genetic, early and late factors, Embracing heterogeneity creates new opportunities for understanding and treating those at clinical-high risk for psychosis, Associations between duration of untreated psychosis and domains of positive and negative symptoms persist after 10 years of follow-up: A secondary analysis from the OPUS trial, Self-concept and Engagement in LiFe (SELF): A waitlist-controlled pilot study of a novel psychological intervention to target illness engulfment in enduring schizophrenia and related psychoses, Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments (SMART-CAT) in first-episode schizophrenia patients: Rationale and trial design, Adaptability and cohesion in youth at clinical high-risk for psychosis: A multi-informant approach, Psychosocial interventions for people with schizophrenia or psychosis on minimal or no antipsychotic medication: A systematic review, The long-term antipsychotic treatment of schizophrenia: A selective review of clinical guidelines and clinical case examples, Perspective on medication decisions following remission from first-episode psychosis, You say “schizophrenia” and I say “psychosis”: Just tell me when I can come off this medication, Relapse rates following antipsychotic discontinuation in the maintenance phase after first-episode of schizophrenia: Results of a long-term follow-up study, Rethinking the risks and benefits of long-term maintenance in schizophrenia, The influence of risk factors on the onset and outcome of psychosis: What we learned from the GAP study, Guest editorial: Special issue on maintenance treatment in schizophrenia, Definitions of relapse in trials comparing antipsychotic maintenance with discontinuation or reduction for schizophrenia spectrum disorders: A systematic review, Predictors of psychosis breakthrough during 24 months of long-acting antipsychotic maintenance treatment in first episode schizophrenia, Reprint of: Negative symptoms predict high relapse rates and both predict less favorable functional outcome in first episode psychosis, independent of treatment strategy, Amygdala connectivity during emotional face perception in psychotic disorders, Diagnostic uncertainty, antipsychotic dosing, and optimal psychosocial interventions: Unanswered questions in first-episode psychosis. 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